Gammaked Background

Product Properties

CERTAIN PRODUCT PROPERTIES SUCH AS SUGAR CONTENT, SODIUM CONTENT, OSMOLALITY, AND VOLUME LOAD MAY INCREASE THE RISK FOR AEs1

Risk factor considerdations1*
                                                                      IGIV Product Characteristics

*Reprinted from with permission from Elsevier. Gelfand EW. Differences between IGIV products: impact on clinical outcome. Int Immunopharmacol. 2006;6:592-599.

Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with immune globulin intravenous (IGIV) products in predisposed patients. Patients predisposed to renal dysfunction include those with any degree of pre-existing renal insufficiency, diabetes mellitus, age greater than 65, volume depletion, sepsis, paraproteinemia, or patients receiving known nephrotoxic drugs. Renal dysfunction and acute renal failure occur more commonly in patients receiving IGIV products containing sucrose. Gammaked does not contain sucrose. For patients at risk of renal dysfunction or failure, administer Gammaked at the minimum concentration available and the minimum infusion rate practicable.


 GAMMAKED PROPERTIES2

  • No sugar
  • Only trace amounts of sodium
  • Close to physiologic osmolality
  • Optimal pH
  • Low infusion volume


References: 1. Gelfand EW. Differences between IGIV products: impact on clinical outcome. Int Immunopharmacol. 2006;6:592-599. 2. GAMMAKED [package insert]. Fort Lee, NJ: Kedrion Biopharma Inc.; 2013.